Objective：We aim to explore the feasibility and safety of the S2b+S3a combined subsegmentectomy for pulmonary nodules between S2 and S3 in the right upper lung. Methods：The clinical data of segmentectomy from 2015 to 2020 in our center was cdlected，the nodule characteristics and perioperative data of the patients received S2b+S3a combined resection was analyzed. Propensity score matching was used to select the right upper lobe（RUL）resection cases with comparable age，gender，and pathological nodule diameter. Results：A total of 46 cases of S2b+S3a resection and 46 matched cases of RUL resection were included. The pathologic malignancy of nodules in the RUL group was higher than that in the S2b+S3a group（P=0.037） and the TNM stage was more advanced（P=0.026）. The nodules of the RUL group were deeper than that in the S2b+S3a group（P=0.005）. The number of lymph node sampled stations and the total number of sampled lymph nodes in the RUL group were larger than those in the S2b+S3a group（P<0.001）. In terms of postoperative data，the drainage volume on the first postoperative day，the total drainage volume，and the duration of chest tube drainage of the S2b+S3a group were all smaller than those in the RUL group. There was no perioperative death in both groups and no postoperative recurrence or death at the follow-up endpoint. Conclusion：S2b+S3a combined subsegmentectomy is a safe and feasible method to manage pulmonary nodules such as early non-small cell lung cancer between S2 and S3 under rational planning.