Irisin is a myokine with biological effects such as promoting white fat browning and improving insulin resistance. Recently，some studies have revealed that irisin has the functions of inhibiting pancreatic β-cell apoptosis，increasing glucose uptake in muscle and adipose tissue，promoting hepatic glycogen synthesis，and inhibiting gluconeogenesis and fat accumulation. Irisin can effectively maintain the glucose homeostasis in the body through the above effects. Based on the above theoretical studies，this paper aims to describe the role of irisin in regulating glucose homeostasis and its mechanism.