The early diagnostic rate of liver cancer is low. Most patients lose the opportunity for surgical resection when they are first diagnosed. It is not eligible for patients to achieve operations mainly due to deficient future liver remnant（FLR） which obstacles the development of liver surgery. Associating liver partition and portal vein ligation for staged hepatectomy（ALPPS） enables patients undergo radical excision by rapid liver hypertrophy，which significantly improves the prognosis of patients. Now ALPPS has substantially gained improvement，which was remarkably controversial for its safety issue in the early stage of practice. This review will elaborate the progress of clinical applications by synthesizing the articles concerning ALPPS.