While facing the current situation of supply and demand contradiction of teaching equipment and lecturing method, the authous intended to give some suggestion of establishing opening laboratory for students after-class usage, which was just based on interesting of students and need of experiments, introducing PBL model in experiment teaching to establish the problem and medical record based learning modality. The article attempted to educate and train medical talents with creativity and all-round development by establishing opening laboratory and introducing of PBL teaching model.