Demanding by the general framework of province-level public health information system, information network management platform, working for occupational disease control in city-level health department, safety production supervision department, labor union and employment company, was constructed according to law of occupational disease prevention and control. Based on J2EE environment, the platform adopted application platform of Oracal database and B/S multi-level architecture, and combined with special information system like Delphi 7.0 and C/S multi-level architecture. Network safety technology, such as tunnel, authentication and encryption technology of VPN was used as well. After a trial application, information sharing,communication and cooperation between different occupational disease control management departments and employing units were realized. Also by setting up hierarchical management mode and complete disease file in occupational hazard enterprises, the occupational disease control working quality had been effectively standardized and improved. According to the above work, the programmed, standardized, information and modernization work of occupational disease prevention and control in the local area had been greatly promoted.