Objective: To explore the career decision-making self-efficacy and coping styles of medical college students and analyze their correlations. Methods: 659 undergraduates of medical university were investigated by the career decision-making self-efficacy scale(CDMSE) and coping style questionnaire(CSQ). Results:① There was gender difference in medical college students’ career decision-making self-efficacy and male college students’ career decision-making self-efficacy was higher than that of female students(P < 0.05). ②Overall career decision-making self-efficacy and each of its dimensions had significant positive correlations with the problem-solving dimension of coping style(P < 0.05), and negatively correlated to self-accusation, fantasy and avoidance(P < 0.05). The self-evaluation and problem-solving of career decision-making self-efficacy had negative correlations with the rationalization of coping style(P < 0.05).③Students with high career decision-making self-efficacy usually used positive ways to deal with problems, and students with low career decision-making self-efficacy used negative coping styles. Conclusion: Certain relations existed between career decision-making self-efficacy and coping styles of medical college students. More attention should be paid to the cultivation of college students’ positive coping styles.