Objective:To investigate the teaching effect of problem－based learning(PBL)combined with case－based learning (CBL) and lecture－based learning (LBL) in clinical practice of gastroenterology. Method: Forty－tow clinical students in the department of gastroenterology of our hospital were randomly divided into two groups,one was trail group and the other was control group. Students in trail group were trained by PBL+CBL+LBL,while students in control group were taught by CBL+LBL. The teaching effect of the two groups were compared. Results:The teaching effect of PBL combined with CBL and LBL group was significantly better than that of the CBL and LBL group(P﹤0.05),that including improving study efficiency and self－learning ability,stimulating study interest,establishing clinical thinking and other aspects. Conclusion:Teaching method of PBL combined with CBL and LBL is better than that of LBL and CBL,and it can contribute to the student’s clinical thinking and practical ability.