To analyze a large general hospital in Jiangsu. This study explored the drug use of hospital overall and particular sections,as well as the types,structures and cost control changes of drug use on medicare and private patients after the implementation of the Basic Medical Insurance Drug List of Jiangsu (2010 Edition). Moreover,this study pays attention to the insured patients’ medication,and provides theoretical basis to promote rational clinical drug use,lower operation risk of health insurance funds and control unreasonable increase of medical expenses.