Medicine occupation spirit＇s development is based on the medical science and the humanities,it has very strong social era. At present,the market competition system,the reform of medical system,tension of relationship between doctor and patient,and the workload of medical occupation produced great impact and challenge to medicine occupation spirit. From a deep understanding of connotation and Influence factors of medicine occupation spirit,and combined with medical deeds,this paper elaborated a path to reconstruct medical occupation spirit during new period.