Objective To study anticancer effect and ultrastructural influence of phosphorus-32 glass microspheres(32 P-GMS) injected in the hepatocellular carcinoma in nude mice.MethodsThe ultrastructural changes of tumor in both the treatment group and control group were examined by transmission electron microscope.ResultsIn the treatment group,a large number of tumor cells were killed and the death rate of tumor cells was much higher(35%-70%).Ultrastructurally,severe nuclear damage was observed in the dead cells.The early characteristics of necrosis such as margination of heterochromatin were also found in some tumor cells.Besides,well-differentiated tumor cells,degenerative tumor cells and some lymphocytes were seen.The skin and muscle close to the tumor were normal.In the control group,the tumor consisted of poor differentiated tumor cells,in which there were only a few appototic cells(5%).ConclusionThe results suggest that the local administration of 32P-GMS produces obviously the anticancer effect.``