Objective: To inquire into diagnosis, and treatment of virilizing and feminizing adrenal syndrome, differential diagnosis between benign and malignant sex hormone producing adrenal neoplasma and, treatment principles of congenital adrenal hyperplasia ( CAH ) . Methods: Eight cases of CAH and 5 cases of sex hormone producing adrenal neoplasma were admitted to hospital during 1986-1996. The former included 3 rare cases of 17 a hydroxylase deficiency. The latter included 3 cases of feminizing adrenal tumor and 2 cases of virilizing adrenal tumor. Results: Weight, size and CT of the tumor, DHEA, 17-ks, sex hormone levels, infiltration, and metastasis were closely related to the degree of differentiation of the tumors. Conclusion: Virilizing and feminizing adrenal neoplasm were removed surgically by different incisions. Modified subcostal incision was recommended as the best choice for huge adrenal mass. Corticoadrenal hormone treatment fo CAH should be individualized according to the different types of the disease. Sex hormones were not suitable for children suffering from 17 hydroxylase deficiency before puberty.