Page 161 - 南京医科大学学报自然科学版
P. 161
第41卷第7期 王梦玮,徐天蔚,王朝霞,等. PD⁃1/PD⁃L1免疫检查点抑制剂在肺癌临床研究中的进展[J].
2021年7月 南京医科大学学报(自然科学版),2021,41(07):1084-1094 ·1091 ·
ic CD8(+)T cells during an acute retroviral infection[J]. for the treatment of non ⁃ small ⁃ cell lung cancer[J]. N
Front Immunol,2019,10:54 Engl J Med,2015,372(21):2018-2028
[9] LIANG S C,LATCHMAN Y,BUHLMANN J E,et al. Reg⁃ [23] GARON E B,HELLMANN M D,RIZVI N,et al. Five⁃
ulation of PD⁃1,PD⁃L1,and PD⁃L2 expression during nor⁃ year overall survival for patients with advanced non⁃small⁃
mal and autoimmune responses[J]. Eur J Immunol,2003, cell lung cancer treated with pembrolizumab:results from
33(10):2706-2716 the phase I KEYNOTE⁃001 study[J]. J Clin Oncol,2019,
[10] DONG H,STROME S E,SALOMAO D R,et al. Tumor⁃as⁃ 37(28):2518⁃2527
sociated B7 ⁃ H1 promotes T ⁃ cell apoptosis:a potential [24] HERBST R S,BAAS P,KIM D W,et al. Pembrolizumab
mechanism of immune evasion[J]. Nat Med,2002,8(8): versus docetaxel for previously treated,PD⁃L1⁃positive,
793-800 advanced non⁃small⁃cell lung cancer(KEYNOTE⁃010):a
[11] PARDOLL D M. The blockade of immune checkpoints in randomised controlled trial[J]. Lancet,2016,387(127):
cancer immunotherapy[J]. Nat Rev Cancer,2012,12 1540-1550
(4):252-264 [25] RECK M,RODRIGUEZ⁃ABREU D,ROBINSON A G,et
[12]RIBAS A,HU⁃LIESKOVAN S. What does PD⁃L1 positive al. Pembrolizumab versus chemotherapy for PD⁃L1⁃posi⁃
or negative mean?[J]. J Exp Med,2016,213(13):2835- tive non⁃small⁃cell lung cancer[J]. N Engl J Med,2016,
2840 375(19):1823-1833
[13] AHMADZADEH M,JOHNSON L A,HEEMSKERK B,et [26] MOK T K,WU Y,KUDABA I,et al. Pembrolizumab ver⁃
al. Tumor antigen⁃specific CD8 T cells infiltrating the tu⁃ sus chemotherapy for previously untreated,PD ⁃ L1 ⁃ ex⁃
mor express high levels of PD⁃1 and are functionally im⁃ pressing,locally advanced or metastatic non ⁃ small ⁃ cell
paired[J]. Blood,2009,114(8):1537-1544 lung cancer(KEYNOTE⁃042):a randomised,open⁃label,
[14] NOGUCHI T,WARD J P,GUBIN M M,et al. Temporally controlled,phase 3 trial[J]. Lancet,2019,393(10183):
distinct PD⁃L1 expression by tumor and host cells contrib⁃ 1819-1830
utes to immune escape[J]. Cancer Immunol Res,2017,5 [27]BRAHMER J,RECKAMP K L,BAAS P,et al. Nivolumab
(2):106-117 versus docetaxel in advanced squamous⁃cell non⁃small⁃
[15] CHANG C H,QIU J,O’SULLIVAN D,et al. Metabolic cell lung cancer[J]. N Engl J Med,2015,373(2):123-
competition in the tumor microenvironment is a driver of 135
cancer progression[J]. Cell,2015,162(6):1229-1241 [28] BORGHAEI H,PAZ⁃ARES L,HORN L,et al. Nivolumab
[16] DURAISWAMY J,KALUZA K M,FREEMAN G J,et al. versus docetaxel in advanced nonsquamous non ⁃ small ⁃
Dual blockade of PD⁃1 and CTLA⁃4 combined with tumor cell lung cancer[J]. N Engl J Med,2015,373(17):
vaccine effectively restores T⁃cell rejection function in tu⁃ 1627-1639
mors[J]. Cancer Res,2013,73(12):3591-3603 [29] KAZANDJIAN D,KHOZIN S,BLUMENTHAL G,et al.
[17] WOO S R,TURNIS M E,GOLDBERG M V,et al. Im⁃ Benefit⁃risk summary of nivolumab for patients with meta⁃
mune inhibitory molecules LAG⁃3 and PD⁃1 synergistical⁃ static squamous cell lung cancer after platinum ⁃ based
ly regulate T⁃cell function to promote tumoral immune es⁃ chemotherapy:a report from the US food and drug admin⁃
cape[J]. Cancer Res,2012,72(4):917-927 istration[J]. JAMA Oncol,2016,2(1):118-122
[18] HUANG A C,POSTOW M A,ORLOWSKI R J,et al. T⁃ [30] WU Y L,LU S,CHENG Y,et al. Nivolumab versus
cell invigoration to tumour burden ratio associated with docetaxel in a predominantly Chinese patient population
anti⁃PD⁃1 response[J]. Nature,2017,545(7652):60-65 with previously treated advanced NSCLC:CheckMate
[19] KAMPHORST A O,PILLAI R N,YANG S,et al. Prolifer⁃ 078 randomized phase Ⅲ clinical trial[J]. J Thorac On⁃
ation of PD⁃1+CD8 T cells in peripheral blood after PD⁃1⁃ col,2019,14(5):867-875
targeted therapy in lung cancer patients[J]. Proc Natl [31] CARBONE D P,RECK M,PAZ⁃ARES L,et al. First⁃line
Acad Sci U S A,2017,114(19):4993-4998 nivolumab in stage IV or recurrent non ⁃ small ⁃ cell lung
[20] WOODARD G A,JONES K D,JABLONS D M. Lung can⁃ cancer[J]. N Engl J Med,2017,376(25):2415-2426
cer staging and prognosis[J]. Cancer Treat Res,2016, [32] FEHRENBACHER L,SPIRA A,BALLINGER M A,et al.
170:47-75 Atezolizumab versus docetaxel for patients with previous⁃
[21] LEMJABBAR⁃ALAOUI H,HASSAN O,YANG Y W,et ly treated non⁃small⁃cell lung cancer(POPLAR):a multi⁃
al. Lung cancer:biology and treatment options[J]. Bio⁃ centre,open ⁃ label,phase 2 randomised controlled trial
chim Biophys Acta,2015,1856(2):189-210 [J]. Lancet,2016,387(130):1837-1846
[22] GARON E B,RIZVI N A,HUI R,et al. Pembrolizumab [33] RITTMEYER A,BARLESI F,WATERKAMP D,et al.

