Page 79 - 南京医科大学学报自然科学版

第42卷第10期 南京医科大学学报（自然科学版）
2022年10月 Journal of Nanjing Medical University（Natural Sciences） ·1421 ·

·临床研究·

外周血S100钙结合蛋白、Hcy及神经元特异性烯醇化酶水平与创

伤性颅脑损伤患者颅内血肿吸收情况及认知功能的相关性分析

张雅旋 ，郭瑞娟 ，张 寅 ，黄保胜 ，王天路 ，王 森 1*
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南京医科大学附属逸夫医院神经外科，重症医学科，江苏 南京 211166
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［摘 要］ 目的：探究外周血 S100 钙结合蛋白、同型半胱氨酸（homocysteine，Hcy）及神经元特异性烯醇化酶（neuron specific
enolase，NSE）水平与创伤性颅脑损伤患者颅内血肿吸收情况及认知功能的相关性。方法：选取2018年1月—2020年12月南
京医科大学附属逸夫医院收治的74例创伤性颅脑损伤患者为观察组，同期于本院体检的75例健康人为对照组，比较两组外周
血S100钙结合蛋白、Hcy及NSE水平；根据血肿吸收情况和是否发生认知功能障碍，将观察组分为吸收良好组、吸收不良组或
有认知功能障碍组、无认知功能障碍组，分别比较各组间S100钙结合蛋白、Hcy及NSE水平，分析观察组血肿吸收情况、认知功
能与外周血S100钙结合蛋白、Hcy及NSE水平的相关性。结果：观察组S100钙结合蛋白、Hcy及NSE水平明显高于对照组；吸
收良好组血清中S100钙结合蛋白、Hcy及NSE水平明显低于吸收不良组；血清内S100钙结合蛋白、Hcy及NSE水平互为正相
关，且均与血肿吸收水平呈负相关，即血肿吸收越好，血清内指标越低；有认知功能障碍组血清中S100钙结合蛋白、Hcy及NSE
水平明显高于无认知功能障碍组；认知功能障碍和血清内S100钙结合蛋白、Hcy及NSE水平均呈正相关，差异均有统计学意义
（P < 0.05）。结论：创伤性颅脑损伤患者血肿吸收情况和认知功能与外周血中S100钙结合蛋白、Hcy及NSE水平具有明显的相
关性，有助于该病的临床诊治。
［关键词］ 创伤性脑损伤；颅内血肿吸收情况；认知功能；S100钙结合蛋白；同型半胱氨酸；神经元特异性烯醇化酶
［中图分类号］ R651.1 ［文献标志码］ A ［文章编号］ 1007⁃4368（2022）10⁃1421⁃05
doi：10.7655/NYDXBNS20221011

Analysis of the relationship between the levels of S100 calcium⁃binding protein，Hcy and

neuron⁃specific enolase in peripheral blood and the absorption of intracranial hematoma
and cognitive function in patients with traumatic craniocerebral injury
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ZHANG Yaxuan ，GUO Ruijuan ，ZHANG Yin ，HUANG Baosheng ，WANG Tianlu ，WANG Sen 1*
Department of Neurosurgery，Department of Critical Care Medicine，Sir Run Run Hospital，Nanjing Medical
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University，Nanjing 211166，China
［Abstract］ Objective：To explore the relationship between the levels of S100 calcium binding protein，homocysteine（homocysteine，
Hcy）and neuron specific enolase（neuronspecificenolase，NSE）in peripheral blood and the absorption of intracranial hematoma and
cognitive function in patients with traumatic craniocerebral injury. Methods：A retrospective analysis was made on 74 patients with
traumatic craniocerebral injury treated in our hospital from January 2018 to December 2020 as the observation group，and 75 healthy
persons who underwent physical examination in our hospital in the same period were selected as the control group. The levels of S100
calcium binding protein，Hcy and NSE in peripheral blood of the two groups were compared. According to the absorption of hematoma
and the occurrence of cognitive impairment，the observation group was divided into good absorption group，poor absorption group or
cognitive impairment group and non ⁃ cognitive impairment group. The levels of S100 calcium binding protein，Hcy and NSE were
compared among the groups. The correlation of hematoma absorption and cognitive function with the levels of S100 calcium binding
protein，Hcy and NSE in peripheral blood was analyzed. Results：The levels of S100 calcium binding protein，Hcy and NSE in the
observation group were significantly higher than those in the control group，the serum levels of S100 calcium binding protein，Hcy and

［基金项目］ 南京市卫生科技发展专项资金（YKK19166）
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通信作者（Corresponding author），E⁃mail：yyaj2013@163.com