This paper was aimed to evaluate comprehensively the level of high ? quality development of public hospitals in 16 cities in Anhui Province in 2020 by using the variation coefficient method，the rank sum ratio method，and the coupling coordination degree model to calculate the coupling coordination development level. The results showed that the high ? quality development level of public hospitals in Hefei，Wuhu and Anqing ranked the top three； while Suzhou，Chizhou and Huangshan ranked bottom. From a regional perspective，the development level of public hospitals in central Anhui was highest，followed by northern Anhui and southern Anhui. The development of public hospitals in 14 cities in Anhui Province had reached the coordinated level，accounting for 87.50%，while the imbalance existed in 2 cities，accounting for 12.50% . From a regional perspective，southern Anhui was on the verge of maladjustment，central Anhui was faced with moderate maladjustment，and northern Anhui was barely coordinated. To improve the high?quality development level of public hospitals in Anhui Province，we need to improve the medical and health service system and promote the coordinated development of public hospitals；strengthen the refined management and improve the operation level of public hospitals；improve the service capacity of public hospitals by focusing on discipline construction；and improve the service mode of public hospitals and patients’satisfaction with medical treatment.