The purpose of the article is to understand the work quality of the Clinical Research Coordinator (CRC)in Nanjing，understanding their job satisfaction，occupational status of the CRC，in order to reduce the turnover rate，stabilize the clinical trial project team，and find effective countermeasures and references basis for improving the quality of clinical research. On the basis of consulting experts and literature review，a online questionnaire was designed to investigate the work quality of 184 CRC in many hospitals in Nanjing. Through the survey analysis，it was found that CRC had a low satisfaction score on workload matching，salary and treatment，promotion opportunities，etc.，and had a high tendency to leave，which had a certain impact on the quality of clinical trials. In view of the quality of CRC’s work，it is necessary to clearly define the laws and regulations，divide the functional scope，establish a unified training and assessment mechanism，a stable office environment， and a reasonable salary system to further enhance the industry recognition of CRC. The administrative department needs to take effective measures to train and manage CRC in a scientific and standardized manner，while CRC also need to improve their self ? knowledge reserves and work capabilities to promote the standardized and professional of China’s CRC industry.