This paper explores the effect of emotional exhaustion on the satisfaction of decision -making of attending physicians and the mediating role of work regulatory focus. Using the emotional exhaustion scale，the work regulatory focus scale and the decision satisfaction scale，this study investigated 300(78%)healthcare workers from a tertiary public hospital in Chongqing. The results showed that the emotional exhaustion score was (21.108 ± 9.135)，with 57.94% of participants being moderately exhausted or above. The total score of decision satisfaction was(15.712 ± 4.152)and correlation analysis showed that emotional exhaustion，promotion focus and prevention focus correlated with decision satisfaction(r=-0.295、0.402、0.488，P＜0.01). The mediating effect test showed that emotional exhaustion could indirectly affect decision satisfaction through the mediating effect of promoting focus and prevention focus (25.41% ，24.77%). It is necessary to set up a professional emotion processing department to establish a proper cognitive structure of the attending physician responsibility system and rationally adjust the focus of regulation of different medical personnel.