Official crimes against epidemic prevention and control frequently occur during the comprehensive epidemic prevention and control work in society，which not only seriously hinders the state management activities but also infringes on the public interests and the safety of residents. From the criminology perspective，the article presents an empirical study of a representative case in Hubei Province based on the Judicial Records Website. It can be concluded that the causes of these epidemic - related crimes of obstructing official duties can be attributed to the individual internal cause and external social factors of the criminal subject. We should start from four aspects：cultivating public responsibility，promoting legal and medical knowledge，improving social security and standardizing law enforcement services，and building an“internal and external integration”system of crime prevention and governance，to reduce the incidence and conversion rate of cases obstructing official duties and ensure the orderly development of epidemic prevention and control.