This study retrospectively collected operational data of three typical specialized - disease wards from records of the cardiovascular department from a tertiary hospital in Nanjing from 2019 to 2021. In order to compare the differences between the two specialized - disease wards and one ordinary ward, the DRG core indicators were analyzed by the Medical Records and Statistics Division，whereas the health insurance cost data were analyzed by the Health Care Division. The result showed that different specialized - disease wards of the Cardiovascular department operate with their own characteristics. The electrophysiological disease ward has great difficulty in interventional operation and a high cost of health insurance. In contrast, the coronary heart disease ward is characterized by as low cost of health insurance and quick patient turnover. Compared with the general disease ward，the specialized - disease ward has a higher concentration of patient types and a higher number of patients requiring surgical operations. Through proper construction of specialized -disease wards, the optimization of department operation, the promotion of academic development，and the intensification of cost control could all be achieved as a new way of development and operation for the future of the cardiovascular department.