This study selected 428 maintenance hemodialysis patients treated at different levels of medical institutions in Yangzhou from September to November 2022 using convenience sampling. Based on the Anderson model,this study adopts SPSS26.0 descriptive analysis,Chi - square test and multiple linear hierarchical regression to explore the status and influencing factors of e - health literacy among maintenance hemodialysis patients. The results showed that these patients’total score of e-health literacy was at a low level and required further improvement. Age(β =- 0.239),frequency of searching Internet health information(β =0.177),self - efficacy(β=0.441),dialysis duration(β=-0.124)and Davies-Stoke score(β=-0.091)were the main contributing factors to thee - health literacy of maintenance hemodialysis patients(P<0.05). Targeted intervention and guidance should be given to patients with older age,long duration of dialysis,higher comorbidity burden,and low self -efficacy. Meanwhile,increasing patients’frequency of online health information search is essential to improve their e-health literacy.