The present study adopted a random sampling method to collect 879 valid online questionnaires from college students in Jiangsu Province，and used SPSS software for data analysis. The study aims to explore the current state of college students’psychological crisis and its family influencing factors under major public health events to improve the effectiveness of college students’psychological crisis intervention. The study found that cold and confrontational family atmosphere，authoritarian and permissive parenting style，constraint and conflict are important risk factors affecting the psychological crisis of college students. The cold and confrontational family atmosphere negatively affect major public health events，the restricted and conflicted family relationship negatively affect college students’awareness of major public health events and psychological crisis knowledge while also increase the risk of psychological crisis. Therefore，we should pay more attention to the impact of family factors on college students’psychological crisis in the context of major public health events，focus on students who are experiencing family caused psychological crisis，strengthen family school education and enhance the positive shaping of family environment on college students’mental health and reinforce the effectiveness of psychological crisis intervention.