Our study surveyed stroke patients during rehabilitation in Jianhu County People’s Hospital. The results showed that patients whose family monthly income is ≥3 000 yuan，having systematic rehabilitation training，higher social support score，have hobbies，family care，family visited times ≥2，and treatment time ＜ 3 h after the onset of stroke have increased by 3.65-9.95 times of high quality of life in the rehabilitation period of middle-aged and elderly stroke patients compared with total disability，severe，moderate，and mild disability increased patients’quality of life. While the proportion of patients with other concomitant diseases，psychological symptoms of anxiety or depression，and treatment time ≥3 h after the onset decreased the quality of life. The nomogram model constructed in our study predicted a total score of up to 280 points. When the predicted scores of these factors reached 164 and above，the incidence of patients with high quality of life reached 90% and above，and the verification results of the nomogram model suggested good accuracy and precision. Therefore， we suggest that hospitals should identify and intervene early on controllable influencing factors supplemented by predictive models and develop personalized rehabilitation programs to improve patients’quality of life.