Chronic disease is characterized by extended disease course，wide prevalence，and high incidence of disability and mortality，with heavy disease burdens and complex situations of prevention and treatment. The management strategy of chronic diseases has risen to the national level. Based on artificial intelligence and mega data，health portrait technology has been gradually applied to various healthcare fields in recent years，becoming a vital issue for further development in mobile health management. The current study summarized the concepts，types，carving procedures，and application progress of health portrait technology in accurate disease risk prediction，intelligent health education，information - based medication management，and digital medical consultation services for chronic diseases. This study aims to provide new ideas and theoretical bases for the practice of chronic disease health management.