This paper aims to understand the quality of the notifiable communicable disease epidemic report of primary medical institutions in Anhui Province in 2021 by conducting a comprehensive evaluation that adopts the fuzzy combination application of entropy weight TOPSIS and RSR method. The results showed that the quality of notifiable communicable disease epidemic reports was the highest in southern Anhui and the lowest in northern Anhui. Among the prefecture -level cities in this evaluation，Anqing and Wuhu ranked the highest， while the bottom two were Lu’an and Xuancheng. The comprehensive quality of notifiable communicable disease epidemic reports decreased in the following order：community health service centers， township hospitals，other institutions like clinics and outpatient departments，and village clinics. The legal management of notifiable communicable disease epidemic reports of primary healthcare institutions in Anhui Province needs to be improved. Primary healthcare institutions should standardize the establishment of notifiable communicable disease epidemic reporting departments，appointing full-time personnel to manage the reporting. We also recommend refining the training mechanism for communicable disease prevention and control personnel， strengthening the coordination among multiple departments including the government，disease control and prevention center，health supervision，and healthcare institutions，while incorporating communicable disease modules into information construction.