The article analyzes the current epidemic prevalence of latent syphilis in Yangzhou City based on the latent syphilis monitoring data from 2014 to 2023，and proposes suggestions for prevention and control strategy. Results show that 12 077 cases of latent syphilis were reported in Yangzhou City from 2014 to 2023， with an increasing trend in incidence. The incidence in males is slightly higher than in females，with the highest proportion of patients in the age group of 50~＜60（20.31%），farmers are the main incidence population （45.50%），mainly of local households（89.62%）. We need to diversify publicity methods and enhance the effectiveness of information dissemination to raise public awareness of prevention and control. It is also vital to emphasize diagnosis and treatment management and improve the monitoring system. Improving relevant laws and regulations and actively seeking policy support to provide institutional guarantees for prevention and control work is also recommended. The integration of cross-sectional resources needs to be strengthened，and a multilevel cooperation mechanism should be promoted to form a joint effort. By mobilizing social forces and relying on specific projects to implement effectively，it is feasible to maximize the positive role of all parties. Additionally，emphasis should be placed on the coordinated development of technological innovation and incentive policies to enhance the overall effectiveness of syphilis prevention and control work.