To analyze the changes in healthcare quality evaluation indicators for hospitalized tuberculosis patients under the diagnosis-related group（DRG）payment system，this study conducted a retrospective analysis using an interrupted time series regression model. The results showed that following the DRG implementation， the total hospitalization costs，average per - day hospitalization costs，medication costs，number of prescribed medication varieties，and length of hospital stay all significantly decreased. The intervention effect of DRG was particularly notable among drug - resistant tuberculosis patients，with significant improvements in indicators of healthcare resource utilization， service efficiency，and quality of care（P＜0.05）. The adoption of the DRG payment model has promoted healthcare institutions to transform their service delivery models and alleviated the financial burden on patients.