The integration of Red Medical Spirit（RMS）and the“great ideological and political course”in medical schools is not only conducive to the implementation of the fundamental task of fostering virtue and nurturing people，but it is also beneficial to the cultivation of medical ethics of medical students and promotes their free and comprehensive development. Additionally，it helps stimulate the vitality of ideological and political teaching in medical schools，playing a significant role in the implementation of the Healthy China strategy and the promotion of Chinese path to modernization. The integration of RMS with the“great ideological and political course”in medical schools faces certain shortcomings，including ideological recognition and identification， curriculum construction，resource platform integration，and talent structure. To this end，the integration of RMS and the“great ideological and political course”in medical schools can be promoted through optimizing course content，making good use of social classrooms，integrating resources，building faculty and institutional support systems，and other paths.