This paper introduces the theoretical perspective of “embodiment” to re-examine Professor Hong Shilü's research practices during the founding period of modern parasitology in China. Hong's outstanding contribution lies beyond merely applying Western parasitological knowledge. Rather, he pioneered an “embodied science” paradigm-through his physical presence in epidemic areas, hands-on technical work, active organizational construction, and direct knowledge transmission. This paradigm emphasizes that scientific understanding originates from direct perception of scientists gained through physically engaged in epidemic settings. Technological invention involves creative transformation that scientists achieve by adapting to local resource constraints. Organizational construction reflects institutionalized embodiment of research entities rooted in local social networks. Knowledge transmission serves as a cultural process of integrating scientific concepts into the daily habits of the general public. Through an in-depth analysis of Hong's “embodied practices” in the prevention and control of diseases such as paragonimiasis and ancylostomiasis, this paper aims to reveal a profound and dynamic mechanism in the localization process of modern science in China, thereby offering critical intellectual resources for reflecting on the practical nature of science and advancing self-reliance and self-improvement in contemporary science and technology.