Under the strategic background of the in-depth integration of new medical science construction and the new generation of artificial intelligence, intelligent medical engineering, as an emerging interdisciplinary major, faces several challenges in talent development, such as the fragmentation of knowledge structures, the disembodying of practical teaching scenarios, and the lack of diversity in teaching approaches. This study provides a theoretical framework for the application of the three-dimensional integration industry-education integration and collaborative education practice teaching model. This model aims to cultivate high-quality, compound and innovative talents that meet the demands of the healthcare industry. By deconstructing and reconstructing the curriculum system, practical platforms and teaching staff, it enables the deep coupling of resources and value co-creation among higher education institutions, clinical practice settings and cutting-edge industrial ecosystems. Thereby, it provides theoretical and practical references for similar institutions in addressing the challenges of interdisciplinary talents cultivation.