Objective To investigate the advantages and feasibility of distal pancreatectomy with en bloc resection of the celiac axis(Appleby surgery) Method We present four cases and analyze the condition of four patients with primary pancreatic cancer who underwent Appleby surgery. Results Among the four cases, three present with adenocarcinoma and one presents with mucinous cystadenoma. There are no revascularization in these four cases, two of which have lymph node metastasis. One has left adrenal gland involved and had it removed during the surgery. All of the four cases have had R0 resection successfully. The time of the operations ranges from three to six hours. There is no severe surgical complications of death. Complications of mild diarrhea and pancreatic fistula are presented in four and delayed gastric emptying is presented in one case, all of which are successfully relieved with conservative treatment. The preoperative abdominal or lumbar back pain presented in three cases are significantly relieved or disappear after the surgery. Transient elevated level of aminotransferase is noted postoperatively, but it comes back to normal after conservative treatment. There is no postoperative changes in biliary ducts . Conclusion This case report shows the feasibility and safety of the distal pancreatectomy with en bloc resection of the celiac axis and the possiblility of complete resection.