Objective: To evaluate the effect of group counseling intervention on career decision-making self-efficacy of nursing students. Methods: 48 junior nursing students in vocational colleges were randomly divided into experimental group and control group. Experimental group were received 8 weeks group counseling. Two groups of students were investigated with the Career Decision Making Self-efficacy Scale（CDMSES）and Coping Style Questionnaire（CSQ）before and after group counseling. Results: After the group counseling, the CDMSES score and mature coping style score in the experimental group were significantly higher than those in the control group (P<0.05); immature coping style scored significantly lower than that of control group (P<0.01). Conclusion: Group counseling intervention can effectively improve nursing students′ career decision-making self-efficacy, and enhance their ability to cope with difficulties.