In recent years, with the update of the concepts of higher education of medicine and the need for the development of medicine course, in the process of major setup and discipline layout of higher education of medicine, the vast majority of institutions of higher learning of medicine have gradually changed into multi-disciplinary universities according to social needs, taking medicine as the main discipline and developing such disciplines as economics, management and humanities, etc. in a harmonious way. The ultimate reason is that this is in line with the objective requirements for the growth of medicine talents, the demands of the time for the development of medicine course, and the request of the economic and social development trend. Looking into the future, a comprehensive educational alliance of multi-disciplines should be established in the process of developing multi-disciplines in higher education of medicine and the path to disciplinary recombination should be explored within a wider range.