Compared with traditional teaching mode, interactive teaching mode can effectively arouse the subjective initiative of students, promote the knowledge complementation among students, enhance the teamwork and collaboration spirit, and improve the quality of teaching. The course of data management and analysis of medical research emphasizes the practical ability and thinking ability of students, the students should use the statistical software to analysis the medical related data, the core of interactive teaching mode is very fit with the requirements of software related courses. Evaluation of teaching effectiveness suggest that the data analysis capabilities of the students who using of interactive teaching mode were significantly better than students using traditional teaching model. Using interactive teaching mode will inject fresh energy to the software teaching courses.