【】 Objective To evaluation of clinical pathway applied to 13 diseases in our hospital. Methods Selected the implementation of clinical pathway from 2012 March to 2014 February and unimplementation from 2009 October to 2011 September of bladder tumor in 13 cases respectively as the experimental group and control group. Set the preoperative hospital days, hospital stays, hospitalization expenses and medicine expenses as the assessment indexs by using Pearson correlation analysis and Hotelling T2 or t test. Results Evaluation indexs of most diseases had a significant positive correlation. On this basis, the difference test also showed that most diseases after the implementation of clinical pathway had significant effect. Conclusion The clinical pathway which had a scientific and reasonable standard and strictly according to the implementation could effectively reduce the hospitalization days, improve medical efficiency, and reduce the cost of hospitalization of patients and the medical cost.