To investigate the application of E-learning platform in the Epidemiology, we performed a survey in 220 undergraduate students from Nanjing Medical University by using questionnaire. We found that E-learning platform has played a positive role in the learning activities of students. Moreover, the students give positive comments on the application of the E-learning platform in the Epidemiology. Further training on teachers and students is needed to extensively understand this platform and the function of the platform also need to be improved. These efforts may add additional value for the teaching activities.