Abstract: The safety management of laboratory chemical reagents is important guarantee for teaching and scientific research at universities. More and more scientific exploratory research has been expanding and frequently carried out in the laboratories in colleges and universities. Varieties and quantity of chemical reagents has been greatly increased, which easily brought laboratory safety xplo hidden trouble. It plays a key role in education and professional training in the universities that the safety management is carried out scientifically and systematically. This paper will state the safety management of laboratory chemical reagents in the universities, how to perfect the related system around the safety management of the laboratories and how to strengthen safe education and precautions.