Based on wechat group talk, the authors applied PBL teaching in the clinical probation of medical students. In urological probation, we compared the results of clinical examination and questionnaire between the students in the traditional PBL teaching group and wechat-basing PBL group. Theory test and survey questionnaire were used among students to investigate the effect of PBL teaching based on wechat platform. Based on our study, PBL teaching based on wechat platform was proved to be effective in improving probation teaching.