Focusing on practical innovation ability training has become the core task of preventive medicine professional training. However, in current preventive medicine education model, students focus on the learning, but ignore the practises, resulting in the innovative thinking and ability cannot meet the needs of current social development. In the past few years, our center focused on the following fore aspects of researches including innovative practice teaching philosophy; theory teaching in the form of a hierarchical and diversification; step by step training their scientific thinking; open laboratory operation and management system. We try our best to improve the innovation practice teaching idea, method, means and mode, construct and optimize the practice teaching system, and found they are helpful in improving the professional innovation ability of preventive medicine undergraduates.