Objectives: Comparison and analysis of the prevention and treatment knowledge and compliance by patients with hypertension from different rural areas, studying the influencing factors, so as to provide reference bases for exploring “country-township-village” cooperative hypertension management strategy. Methods: Descriptive analysis such as rate were applied to analyze awareness of knowledge and compliance, inferential analysis such as Chi-square test and logistic regression were applied to analyze the influencing factors. Results: The awareness rate of knowledge was 75.6% (Southern 64.8%,Middle 74.6%,Northern 84%), marital status, educational level and different areas were its influencing factors. 88.2% of hypertension patients’ compliance of medicine intake were better (Southern 92.9%,Middle 92.6%,Northern 79%), different areas and awareness of knowledge were its influencing factors. Conclusions: Different areas should be combined with their own characteristics, building a “country-township-village” hypertension longitudinal cooperation team, improve patients’ knowledge and compliance.