Objective: To explore the relationship among college students’ death attitude, sense of meaning in life and obsession symptoms. Methods: 1603 college students were surveyed with Death Attitude Profile-Revised(DAP-R),obsession symptom subscale of Symptom Check List 90(SCL一90) and Intensity of Meaning in Life Scale for College Students which was self-designed. Results: (1) College students’ death attitude, sense of meaning in life and obsession symptoms were significantly correlated with each other. (2)College students’ sense of meaning in life had a overall mediating effect between the acceptance of natural death dimension of death attitude and obsession symptoms. It had a partial mediating effect between the other four dimensions of death attitude and obsession symptoms. Conclusion: College students’ sense of meaning in life had a mediating effect between death attitude and obsession symptoms.