To innovate teaching mode,promote the teaching reform of university,and realize the transformation from teachers" teaching to students" self study, the combination of Team-Based Learning (TBL) and aSnewSclassroomSpattern-roleSexchangeSbetweenSteachingSand learning was used for Toxicology experiment teaching. In the present study, the pre-class learning, classroom effects, and other dimensions of differences were investigated according to the questionnaire survey results. Moreover, the students" satisfaction after the implementation of the teaching method was also discussed. Therefore, the current work will provide some basis for the application of role changing teaching in the toxicology experiment.