Abstract Objective：To investigate the occupational burnout and the relationship between Psychiatric medical staff's Occupational burnout and Social support. Methods: 360 psychiatric medical staff were sampled in mental hospitals and general hospitals of Inner Mongolia and investigated by Perceived Social Support Scale (PSSS) and Maslach Burnout Inventory-Human Service Survey (MBI-HSS) and then the results were analyzed. Results: There were statistical significance in sex, age, education level, positional titles, profession, working life and management positions of each dimension of mental health worker’s occupational burnout in Inner Mongolia; There was a significant different in social support between the staff with different sex, marital status, education level, working life and management positions；Significant negative correlation also exists among social support and negative emotions in Occupational burnout，including emotion exhaustion and depersonalization．Significant positive correlation exists among social support and personal accomplishment. The recession analysis showed that sex, formation, management positions, working years, and social support have a significant role in the prediction of emotional exhaustion; social support, sex, management positions, positional titles, and age have a significant role in the prediction of depersonalization; social support, management positions, positional title, and age have a significant role in the prediction of sense of personal achievement. Conclusions: We should pay attention to the problem of occupational burnout of psychiatric medical staff and fully consider the influence of social support to occupational burnout.