Objective To explore the quality of life(QOL) and its influential factors of rural T2DM patients. Methods 291 T2DM patients were investigated with self-designed questionnaire and DSQL, using univariateSanalysis and multivariate analysis to explore the influential factors. Results The QOL of T2DM patients was poor, and the total score of DSQL was 54.99±11.88; the QOL of female,SlowScultureSdegree, long time sitting, lack of exercise, other chronic diseases, and mental burdens was lower. Conclusion Focusing on the female and lowScultureSdegree patients, strengthening the prevention of chronic diseases, valuing the psychological health and encouraging moderate exercise had great significance to improve the QOL of T2DM patients.