This paper firstly described the development and characteristic? of “MOOCs + Flipped Classroom” based on the perspective of the interaction of professor-student in universities; Second, we analyzed the change of the interaction model of professor-student in universities through comparative method; Third, we demonstrated that the interaction of professor-student in the context of “MOOCs + Flipped Classroom” could lead to new requirements for the professors’ abilities, new opportunities for their career development and new requirements for the students’ independent?learning?abilities. Moreover, it is very significant?to train college students' innovative thought.