Objective To assess the turnover intention and the related factors among the nurses in 2-class and above general hospital of Lianyungang, and provide theoretical reference for nursing managers to formulate relevant policies. Methods By convenience sampling, 446 nurses were selected and investigated by using general demographic scale, the turnover intention scale and job satisfaction scale. Result The total score of turnover intention score was 14.41±3.67, at a high level. The dimensions of job satisfaction were negatively correlated with turnover intention (P＜0.01). The result of Multiple linear regression analysis showed that there were statistically significant in the management, the balance between family and work, marriage, salary and benefits, age and working load. Conclusion It is recommended that nursing managers should take scientific measures to reduce the loss of nurses according to their own characteristics and career development stages.