The concept of general education and the curricula design have become the consensus of the development of higher education in the world. Chinese universities have gradually formed the path from the national conditions and the reality of the school on the basis of the general education from developed countries. Multidisciplinary medical universitiesSonce fell into the development situation of overspecialization because of the relatively "specialized" discipline background. It is the common choice of the medical universities to add the elective courses of humanities to make up the deficiency of the existing curriculum system. Four cases of university are selected to analyze and compare the construction and implementation of the humanities elective courses in the paper. Then, choosing one of the university curriculum system reform as an example, it is reasonable to construct the general curriculum system in the existing framework of medical education, which shows the effective connection between the public compulsory courses, elective courses and medical humanities courses, the humanistic penetration in the basic medical courses and the clinical skills training, highlighting the humanistic orientation of the whole curriculum by setting PBL course which breaks boundaries of humanities and medical. And puts forward the idea of curriculum improvement in the combination of general education and medical professional education: it"s need to seek the balance between the development of higher education in the internal and external relevance and face the problem of localization of general education concept in the idea level; it"s also need to pay attention to whether the idea is put into practice and negative problems of professionalism, systematization and structuralism because of breaking barriers of the existing curriculum system in the practical level.