With the advent of the WeMedia era, the traditional teaching model is facing great challenges. College students are no longer satisfied with studying in the traditional classroom. By making use of the simplicity and extensiveness of information acquisition in the WeMedia era, innovating a new type of teaching mode with students as the main body has become a major trend in the development of teaching mode in the new era. Through the analysis of the use of WeChat and micro-lecture in different grades of college students, this paper explores the feasibility of the auxiliary teaching mode of "WeChat+micro-lecture" in college teaching, aiming at exploring a mobile learning mode suitable for college students in the new era.