Abstract: In order to explores the significance of completeness of plan and assessment mechanism and verifies the feasibility of the quantitative methods, exhausting the collection of the relevant documents of infectious disease prevention and control published in Zhejiang and Shanghai from 2000 to 2017. Extracting and quantifying the relevant fields, and comprehensively forming the quantitative index "completeness of plan and assessment mechanism ". Comparing the time series changes and similarities of completeness of plan and assessment mechanism of infectious disease system between Zhejiang and Shanghai. The health system macro model, Spearman correlation, linear regression and other methods were used to analyze the relationship between the results and incidence of Class A and B legal infectious diseases. The results showed that the completeness of plan and assessment mechanism of infectious disease system between Zhejiang and Shanghai had improved gradually from 2000 to 2017(46.85% vs 58.95% in 2017). The trend of incidence of notifiable infectious diseases showed significant negative correlation to that of the coverage in these two places (p<0.01). By the end of 2017, the plan and assessment mechanism for infectious diseases in Zhejiang and Shanghai has been initially improved. However, the two places still have problems of low coverage of evaluation indicators and weak implementation. By proposing corresponding policy recommendations, it is expected to further improve the plan and assessment mechanism; The results of quantitative evaluation of completeness of plan and assessment mechanism for infectious disease system in Zhejiang and Shanghai are credible.