Objective: Compare and analyze the differences in health needs between infectious diseases in Zhejiang and Shanghai,explore the significance of grasping health needs in both places and try to verify the feasibility of its quantitative methods. Methods: Systematically collects the three-level prevention sensitive indicators of infectious diseases published by the governments of Zhejiang and Shanghai , and uses descriptive methods to analyze the changes in the public health needs of Zhejiang and Shanghai, and uses spearman correlation and regression analysis to grasp the relationship between public health needs and the incidence of infectious diseases. Results: The degree of public health needs of infectious diseases in Zhejiang increased from 0% in 2004 to 70.59% in 2017, and Shanghai increased from 73% to 76.8%. The two places grasp the public health needs to the extent of infectious diseases. There is a negative influence relationship (P is less than 0.01), and the correlation coefficients are -0.611 and -0.937, respectively. Conclusion: The appropriate infectious disease health system should be able to accurately grasp the public health needs. Shanghai grasp public health needs for health outcomes better than Zhejiang , but the degree of need for the two places is still insufficient. The method used in this study to quantify the evaluation is scientifically feasible and can be applied to research in other fields.