Objective: To analyze and compare the effective utilization of infectious disease information between Zhejiang and Shanghai and explore the feasibility of quantifying the effective utilization of infectious disease information. Methods: Literatures and information reports on the utilization of infectious disease information published in Zhejiang and Shanghai were collected systematically, and the effective utilization degree was calculated quantitatively. Spearman correlation and linear regression were used to analyze the relationship between the effective utilization of infectious disease information and the incidence of class a and b infectious diseases. Results: The effective use of information on infectious diseases in Zhejiang increased from 0.3% in 2000 to 9.8% in 2017, and from 2.9% in 2000 to 17.5% in Shanghai. There was a significant negative correlation between the timeliness of Zhejiang and Shanghai and the incidence of class a and b infectious diseases (p<0.01), with 47.2% and 79.2% explaining the incidence of infectious diseases respectively. Conclusion: The effective use of information of infectious diseases in Zhejiang and Shanghai is different, but the use of information in Zhejiang is low. Timely identification of epidemic information of infectious diseases, early warning and prediction, implementation of intervention measures, emergency response and evaluation of prevention and control effects are the preconditions for the control of infectious diseases, the reduction of morbidity and the prevention and control of infectious diseases. Both places still need to enhance the effective use of information on infectious diseases; It is scientifically feasible to quantify the effective use of infectious disease information in a country (or region) and can be extended to other public health areas or regions.