Abstract: Based on the characteristics of public health and the teaching concept of "integration of ideological and political elements with professional knowledge", we carried out a curriculum-based teaching reform in Nanjing Medical University. Taking the course of "Introduction to Preventive Medicine" as an example, we used both Case Based Learning and Team-Based Learning methods synthetically, focusing on integrating the scientific spirit of exploration and the sense of responsibility into the teaching process of professional knowledge. The aim of this reform is to guide students to form a correct professional ethics and social responsibility, and to establish correct values, positive outlook on life, and scientific outlook of the world.